Effect of the new antiallergic drug 11-oxo-11H-pyrido[2,1-b]quinazoline-2-carboxylic acid on inflammatory reactions and platelet aggregation.
MixedOthermale
Model: Ultraviolet-induced erythema in guinea pigs, histamine-induced intradermal vascular permeability, carrageenin, dextran and compound 48/80 hind paw oedema, wound healing in rats, and endotoxin-induced diarrhoea in mice
Sm 857 had no effect on UV erythema, histamine-induced vascular permeability, carrageenin paw oedema, wound healing, analgesia or platelet aggregation. It inhibited dextran-induced paw oedema more strongly than tranilast and inhibited endotoxin-induced diarrhoea in mice to a similar degree as trani…
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