Effects of methyl (+)(3S)-1,2,3,4-tetrahydro-3-hydroxy-methyl-beta-carboline-2- carbodithioate (THC), a new hepatoprotective agent, on acute liver injuries induced by various hepatotoxic substances in mice and rats.
MixedChemical/toxinInbred strain rats (not further specified)MaleOralConcurrent with hepatotoxin for 4 consecutive days; from the day after carbon t…
Model: Chemically induced acute liver injury: carbon tetrachloride, bromobenzene, D-galactosamine and alpha-naphthylisothiocyanate in rats, allyl alcohol in mice; plus in vitro rat liver microsomal lipid peroxidation
THC suppressed the rise in plasma transaminases and hepatic lipid content caused by carbon tetrachloride when given concurrently and also when given after the toxin, confirmed histopathologically. It protected against bromobenzene, galactosamine and alpha-naphthylisothiocyanate injury but not again…
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