Kappa-selective opiate antagonist nor-binaltorphimine improves outcome after traumatic spinal cord injury in rats.
RatSpinal cord injuryContusionmaleIntravenous and intrathecal10 mg/kg intravenously; 0.1 mg/kg intrathecally15 min after impact trauma
Model: Impact trauma to the T-9 spinal cord segment
Nor-BNI at 10 mg/kg intravenously given 15 min after injury significantly improved neurological recovery on both Tarlov motor score and inclined plane testing, and intrathecal nor-BNI at 0.1 mg/kg, a systemically ineffective dose, also significantly improved recovery.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.