A novel therapy, using Ghrelin with pegylated G-CSF, inhibits brain hemorrhage from ionizing radiation or combined radiation injury.
MouseRadiationB6D2F1/JFemaleSubcutaneous for both, in 0.2 mLGhrelin 113 micrograms/kg; pegylated G-CSF 1000 micrograms/…First doses 24 h after irradiation or combined injury
Model: 9.5 Gy whole-body cobalt-60 gamma irradiation alone, or followed within 1 h by a 15% total body surface area skin wound
Ghrelin with pegylated G-CSF reduced brain haemorrhage after radiation and combined injury, restored platelet counts, ghrelin receptors, ATP and phospho-AKT, and lowered active caspase-3.
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