PebbleAtlas
PEBBLE / ATLAS
Open research access
PRECLINICAL PUBLICATION · 1988

Delayed treatment with nerve growth factor reverses the apparent loss of cholinergic neurons after acute brain damage.

Rat / TBI

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 3396647 ↗1988Reported benefit

Delayed treatment with nerve growth factor reverses the apparent loss of cholinergic neurons after acute brain damage.

RatTBIUnspecifiedIntraventricularDelayed treatment started 1, 2 and 3 weeks after injury, once most neurons were…

Model: Axotomy of septal cholinergic neurons by acute brain damage (fimbria-fornix type lesion)

NGF started 1, 2 or 3 weeks after axotomy caused a marked reappearance of apparently lost septal cholinergic neurons, indicating the loss reflects reduced detectability of neurotransmitter enzyme rather than neuronal death.

Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.