Gastroprotective effect of pentacaine: role of mast cells.
RatChemical/toxinInbred strain not specifiedFemaleDose-dependent protection reported; specific doses not stat…Before ethanol exposure
Model: Acute haemorrhagic gastric lesions induced by ethanol
Pentacaine dose-dependently prevented ethanol-induced acute haemorrhagic gastric lesions. Untreated rats showed extensive surface epithelial disruption, deep mucosal necrosis, mast cell degranulation or destruction and microvascular derangement, all of which were absent after pentacaine treatment.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.