PRECLINICAL PUBLICATION · 2016

Delivery of Flightless I siRNA from Porous Silicon Nanoparticles Improves Wound Healing in Mice.

Mouse / Wound

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Flightless I small interfering RNA loaded into chitosan-coated thermally hydrocarbonised porous silicon nanoparticles

PMID 33465882 ↗2016Reported benefit

Delivery of Flightless I siRNA from Porous Silicon Nanoparticles Improves Wound Healing in Mice.

MouseWoundIntradermal injectionLoading of the order of 50 micrograms of siRNA per mg of po…

Model: Acute excisional skin wounds

Intradermal delivery of Flightless I siRNA loaded porous silicon nanoparticles significantly improved healing of acute excisional wounds compared with controls from day 5 onwards, with reduced Flightless I expression and increased keratinocyte migration and proliferation.

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.