Antibodies Against Lysophosphatidic Acid Protect Against Blast-Induced Ocular Injuries.
RatTBIBlast / overpressureSprague DawleyMalen = 6 animals per group for all outcome measures; overall total…Intravenous25 mg/kgOne hour after blast exposure
Model: Single primary blast overpressure exposure in an Advanced Blast Simulator, peak positive static pressure approximately 19 psi with a positive phase duration of 4 to 5 ms, animals prone and facing the shockwave
Blast raised several plasma LPA species at 1 and 4 hours, and a single 25 mg/kg intravenous dose of anti-LPA antibody at 1 hour preserved visual acuity at days 2 and 6, prevented the fall in electroretinogram amplitudes, reduced retinal degeneration and blocked Muller cell activation, although acui…
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