The protective effect and mechanism of COA-Cl in acute phase after spinal cord injury.
RatSpinal cord injuryContusionSprague-Dawley6 mg/kgAcute group dosed immediately after injury; subacute group dosed from 4 days af…
Model: Contusion spinal cord injury at the T9 vertebra produced with a weight-drop device
COA-Cl given immediately after injury significantly improved BBB score and inclined plane performance and significantly reduced cavity volume and apoptosis, with increased pERK/ERK at 7 days, whereas administration beginning 4 days after injury produced no significant motor improvement, indicating…
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