Shikonin ameliorates lipoteichoic acid-induced acute lung injury via promotion of neutrophil apoptosis.
MouseEndotoxin/LPSC57BL/6Male
Model: Lipoteichoic acid-induced acute lung injury
Shikonin significantly attenuated lipoteichoic acid-induced acute lung injury, decreasing pulmonary neutrophil accumulation and TNF-alpha, IL-1 beta and IL-6 expression, and promoted neutrophil apoptosis through increased caspase-3 activation and reduced Mcl-1, with no change in Bcl-2.
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