Canna x generalis L.H. Bailey rhizome extract ameliorates dextran sulfate sodium-induced colitis via modulating intestinal mucosal dysfunction, oxidative stress, inflammation, and TLR4/ NF-kB and NLRP3 inflammasome pathways.

PMID 33301917 ↗2020Reported benefit

Canna x generalis L.H. Bailey rhizome extract ameliorates dextran sulfate sodium-induced colitis via modulating intestinal mucosal dysfunction, oxidative stress, inflammation, and TLR4/ NF-kB and NLRP3 inflammasome pathways.

MouseChemical/toxinC57BL/6Male100 and 200 mg/kgGiven after induction of dextran sulfate sodium colitis

Model: Acute ulcerative colitis induced by 4% dextran sulfate sodium

The extract improved disease activity index, body weight loss and colon shortening, attenuated colonic histopathological change and inflammatory cell infiltration, raised GSH, SOD and catalase, suppressed MDA, myeloperoxidase, nitric oxide and pro-inflammatory cytokines, downregulated LPS/TLR4, NF-…

Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.

Canna x generalis L.H. Bailey rhizome extract ameliorates dextran sulfate sodium-induced colitis via modulating intestinal mucosal dysfunction, oxidative stress, inflammation, and TLR4/ NF-kB and NLRP3 inflammasome pathways.

Evidence by therapy association

Canna x generalis L.H. Bailey rhizome extract ameliorates dextran sulfate sodium-induced colitis via modulating intestinal mucosal dysfunction, oxidative stress, inflammation, and TLR4/ NF-kB and NLRP3 inflammasome pathways.