PEGylated and Acylated Elabela Analogues Show Enhanced Receptor Binding, Prolonged Stability, and Remedy of Acute Kidney Injury.
MouseIschaemia-reperfusionRenalC57BL/6malePal-E11 showed therapeutic effects when given at 24 h after ischaemia-reperfusi…
Model: Renal ischaemia-reperfusion induced acute kidney injury in mice, with in vitro hypoxia-reperfusion and cisplatin injury in cultured renal tubular cells
Palmitoylated and PEGylated E11 analogues showed improved plasma stability and APJ binding compared with E11, protected cultured renal tubular cells against hypoxia-reperfusion and cisplatin injury, and produced greater renoprotection than E11 in mice with renal ischaemia-reperfusion injury. Pal-E1…
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