Vitamin D/VDR attenuate cisplatin-induced AKI by down-regulating NLRP3/Caspase-1/GSDMD pyroptosis pathway.
MouseChemical/toxinWild type, VDR knockout and renal tubular cell specific VDR overexpressing mice; background strain not statedHigh dose in wild type mice and low dose in tubular VDR ove…Pretreatment before cisplatin administration
Model: Cisplatin induced acute kidney injury in mice, with parallel in vitro cisplatin injury in human tubular epithelial (HK-2) cells
In wild type mice, high dose paricalcitol pretreatment alleviated cisplatin induced loss of renal function, tissue injury and cell death, upregulated VDR and reduced NLRP3, GSDMD-N, cleaved caspase-1 and mature IL-1 beta. VDR knockout mice showed more severe renal injury and greater pyroptosis prot…
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