Effects of oxygen generating scaffolds on cell survival and functional recovery following acute spinal cord injury in rats.
RatSpinal cord injuryUnspecifiedSprague-DawleyFemaleLocal implantation (transplantation into the spinal cord injury site)At the time of acute spinal cord injury
Model: Acute spinal cord injury in rats with scaffold transplantation into the injury site
Twelve weeks after transplantation, cavity areas at the injury/graft site were significantly reduced, revascularisation was improved as shown by vWF immunostaining, nerve fibre regeneration occurred in the lesion and significant locomotion recovery was observed. In vitro, scaffolds enhanced mesench…
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