GLP-2 Prevents Neuronal and Glial Changes in the Distal Colon of Mice Chronically Treated with Cisplatin.
MouseChemical/toxinC57BL/6Femalen = 24 mice; control n=3, vehicle n=3, GLP-2 n=6, cisplatin n=6…Intraperitoneal50 micrograms/kgCo-administered, started on the same day as the first cisplatin dose
Model: Chronic cisplatin-induced colonic mucosal and enteric nervous system injury, cisplatin 4 mg/kg intraperitoneally twice weekly for 4 weeks with subcutaneous saline to limit nephrotoxicity
[Gly2]GLP-2 co-administration prevented the cisplatin-induced loss of total myenteric neurons, nNOS-immunoreactive neurons and SOX-10-immunoreactive glia and normalised IL-1beta and IL-10. Protection was partial, since weight loss, reduced mucosal area and PAS staining, reduced GFAP and S100beta an…
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