Impact of uric acid on liver injury and intestinal permeability following resuscitated hemorrhagic shock in rats.
RatHaemorrhage/shockUnspecifiedWistarMaleAdministered during resuscitationDuring resuscitation after haemorrhagic shock
Model: Resuscitated haemorrhagic shock with ischaemia-reperfusion, treatment given during resuscitation
Uricase added to resuscitation lowered circulating and hepatic uric acid and prevented hepatolysis, hepatic apoptotic and inflammatory mediator rises at 24 and 72 hours, and prevented shock-induced enteric hyperpermeability and endotoxaemia.
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