Concussive head injury exacerbates neuropathology of sleep deprivation: Superior neuroprotection by co-administration of TiO2-nanowired cerebrolysin, alpha-melanocyte-stimulating hormone, and mesenchymal stem cells.
RatTBIClosed-head / concussionAlpha-MSH 250 micrograms/kg conventional or 100 micrograms…
Model: Concussive head injury combined with 48 hours of sleep deprivation
Combined sleep deprivation and concussive head injury produced greater blood-brain barrier leakage and brain pathology than either insult alone, with lower alpha-MSH and BDNF and higher TNF-alpha. Combined alpha-MSH, mesenchymal stem cells and cerebrolysin were neuroprotective, and TiO2-nanowired d…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.