PRECLINICAL PUBLICATION · 2020

Mechano-Responsive, Tough, and Antibacterial Zwitterionic Hydrogels with Controllable Drug Release for Wound Healing Applications.

Rabbit / Wound

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Mechano-responsive poly(sulfobetaine methacrylate) hydrogel cross-linked with diacrylated Pluronic F127 micelles loaded with a hydrophobic antimicrobial drug

PMID 33183010 ↗2020Reported benefit

Mechano-Responsive, Tough, and Antibacterial Zwitterionic Hydrogels with Controllable Drug Release for Wound Healing Applications.

RabbitWoundmaleTopical dressing applied to the wound

Model: Acute skin wounds in mice

The micelle cross-linked hydrogel reached ultimate tensile strength of 112 kPa, tensile strain up to 1420% and compressive stress up to 1.41 MPa, with skin adhesiveness of about 6 kPa that did not fall significantly over repeated adhesion cycles. Drug release was controlled by the extent and number…

Extraction: extract · Supplied extraction confidence: 0.5. Machine-extracted fields require source verification.