Omega-3 fatty acids ameliorate doxorubicin-induced cardiorenal toxicity: In-vivo regulation of oxidative stress, apoptosis and renal Nox4, and in-vitro preservation of the cytotoxic efficacy.
RatChemical/toxinWistar albinofemalen = Five groups of 7 to 8 rats eachOral25, 50 and 100 mg/kg/dayPretreatment for 4 consecutive weeks; doxorubicin given 24 h after the last ome…
Model: Acute cardiorenal toxicity induced by a single intraperitoneal injection of doxorubicin 200 mg/kg, with assessment 48 h later
Doxorubicin raised serum creatine kinase about 2.4-fold and urea and creatinine 2-fold and 2.6-fold. Omega-3 at 25, 50 and 100 mg/kg suppressed creatine kinase by 25%, 27% and 57%, urea by about 24%, 40% and 44% and creatinine by 36%, 46% and 59%. Cardiac and renal MDA fell by 26/45/40% and 19/21/3…
Extraction: extract · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.