Human Umbilical Cord-Derived Mesenchymal Stem Cell Therapy Effectively Protected the Brain Architecture and Neurological Function in Rat After Acute Traumatic Brain Injury.
RatTBIWeight-drop / impact-accelerationSprague-Dawley (pathogen free)Malen = 30 rats initially allocated equally to three groups (n = 10…Intravenous injection1.2 x 10 cells per animal (exponent not rendered in the ret…3 h after traumatic brain injury
Model: Marmarou weight-drop closed head traumatic brain injury: 200 g weight (6 mm metal ball) dropped from 2.5 cm onto the left frontal bone (3 mm posterior to the coronal suture, 1.5 mm lateral to midline), impact velocity 6 m/s, dwell time 150 ms, 10 degrees from vertical, under 2.0% isoflurane
Cell-treated animals showed significantly better corner and inclined plane test performance at days 3 to 28, smaller brain ischaemic volume on magnetic resonance imaging at day 28, and lower inflammatory, oxidative stress, apoptotic, fibrotic, brain oedema and DNA damage markers, with higher angiog…
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