Terlipressin relieves intestinal and renal injuries induced by acute mesenteric ischemia via PI3K/Akt pathway.
RatIschaemia-reperfusionIntestinal / mesentericSprague-Dawley (specific pathogen free)MaleIntravenous via femoral vein cannula0.5 mL of an 8 microgram/mL terlipressin solution as a bolu…Bolus given immediately after unclamping of the superior mesenteric artery, wit…
Model: Acute mesenteric ischaemia-reperfusion: superior mesenteric artery clamped with a microaneurysm clip for 1 h followed by reperfusion, under pentobarbital anaesthesia (30 mg/kg intraperitoneally) and mechanical ventilation, with midline laparotomy
Terlipressin and norepinephrine both restored mean arterial pressure, reduced intestinal and renal injury scores, lowered blood urea nitrogen and creatinine, and improved survival compared with untreated mesenteric ischaemia (mortality 85.7% with a median survival of 3 h). Only terlipressin reduced…
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