Protectin DX promotes epithelial injury repair and inhibits fibroproliferation partly via ALX/PI3K signalling pathway.
MixedEndotoxin/LPSC57BL/6n = n = 6 per group across four groups; in vitro three independ…Intraperitoneal200 ng per mouse in 0.1 mL normal saline in vivo; 1-100 nmo…After intratracheal LPS
Model: Endotracheal injection of LPS (E. coli 055:B5) 10 mg/kg in 30 uL, assessed at 6, 24, 48 and 72 h
Protectin DX reduced lung injury score, wet/dry ratio, BALF protein and cytokines, promoted alveolar type II cell proliferation and wound repair, reduced apoptosis and suppressed TGF-beta-driven fibroproliferation.
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