Cytokine activin C ameliorates chronic neuropathic pain in peripheral nerve injury rodents by modulating the TRPV1 channel.
MixedOtherRats, Sprague-Dawley; wild-type and TRPV1 knockout miceMale (rats)Intrathecal; local pre-administrationLocal pre-administration in established neuropathic pain
Model: Sciatic nerve axotomy and spinal nerve ligation in rats; chronic constriction injury in mice
Intrathecal activin C dose-dependently inhibited neuropathic pain and local pre-administration reduced pain behaviour, DRG macrophage infiltration and spinal microgliosis, with the effect abolished in TRPV1 knockout mice.
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