Ameliorative effects of escin on neuropathic pain induced by chronic constriction injury of sciatic nerve.
RatOtherSprague-DawleyMaleIntragastric7, 14 and 28 mg/kgFrom the third day after surgery
Model: Chronic constriction injury of the sciatic nerve; additional formalin and carrageenan acute inflammatory pain models
Escin widened the thermal threshold, lowered TNF-alpha and IL-1beta, suppressed TLR4/NF-kappaB signalling, reduced GFAP and NGF, and improved viability of LPS-injured PC12 cells.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.