P7C3-A20 treatment one year after TBI in mice repairs the blood-brain barrier, arrests chronic neurodegeneration, and restores cognition.
MouseTBIBlast / overpressureC57BL/6JMalen = 15 sham-vehicle, 25 TBI-vehicle, 25 TBI-P7C3-A20; western b…Intraperitoneal10 mg/kg/day in vivo; 0.03-5 uM in vitroChronic arm began 12 months after a single TBI; acute arm dosed 18 h before and…
Model: Multimodal TBI using membrane rupture at 20 PSI generating an approximately 1.0-1.5 ms air jet of 137.9 +/- 2.09 kPa across the untethered head
P7C3-A20 started one year after TBI restored spatial memory, arrested axonal degeneration and repaired blood-brain barrier endothelium, tight junction proteins and pericyte density, although neuronal loss and motor slowing were not corrected.
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