Nilvadipine suppresses inflammation via inhibition of P-SYK and restores spatial memory deficits in a mouse model of repetitive mild TBI.
MouseTBIClosed-head / concussionhTauMale and femalen = 72 mice, n = 12 per group across six groups; tau immunoassa…Intraperitoneal2 mg/kg in 100 uLFirst dose immediately after the last injury, while still anaesthetised
Model: Repetitive mild TBI, five closed-head impacts at 48 h intervals, 3 mm blunt tip, 5 m/s, 1.0 mm depth, 200 ms dwell
Racemic nilvadipine improved motor and spatial memory deficits and reduced astrogliosis, microgliosis, CD68 and P-SYK, whereas ARC031 improved memory and corpus callosum gliosis but not motor deficits or cortical astrogliosis.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.