Thioredoxin-albumin fusion protein prevents urban aerosol-induced lung injury via suppressing oxidative stress-related neutrophil extracellular trap formation.
MouseChemical/toxinICRMaleIntravenous3.5 nmol protein per mouseImmediately before intratracheal urban aerosol administration
Model: Intratracheal administration of urban aerosol particulate matter (200 micrograms per mouse) in 0.5% methylcellulose, inducing acute lung injury
HSA-Trx pre-treatment significantly reduced urban aerosol-induced BALF leukocyte and neutrophil influx (neutrophils 0.96 +/- 0.12 in aerosol group versus 0.58 +/- 0.12 with HSA-Trx, arbitrary cell units as reported), lowered BALF protein concentration, inhibited induction of pro-inflammatory cytoki…
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