Sphingosine 1-phosphate protects against radiation-induced ovarian injury in female rats-impact on mitochondrial-related genes.
RatRadiationSprague-DawleyFemalen = 18 rats, 3 groups of 6; 3 per group sacrificed at 24 h and…Intraperitoneal0.5 mg/kgStarted 72 h before irradiation and continued until sacrifice
Model: Radiation-induced ovarian injury: 6-MV X-ray to the lower abdominal reproductive area, total dose 2 Gy
Irradiation at 2 Gy lowered serum AMH, disrupted ovarian architecture and reduced follicle counts by 72 h. S1P significantly preserved serum AMH at 72 h, limited histological disorganisation and gave significantly higher follicle counts than radiation alone. Mitochondria-related genes were broadly…
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