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PRECLINICAL PUBLICATION · 2020

Human Gut Commensal Membrane Vesicles Modulate Inflammation by Generating M2-like Macrophages and Myeloid-Derived Suppressor Cells.

Mouse / Wound

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 33028617 ↗2020Reported benefit

Human Gut Commensal Membrane Vesicles Modulate Inflammation by Generating M2-like Macrophages and Myeloid-Derived Suppressor Cells.

MouseWoundFemaleIntraperitoneal

Model: Excisional skin wound, alongside acute inflammation models comprising dextran sodium sulfate colitis, zymosan peritonitis and carbon tetrachloride induced fibrosis

Membrane vesicles ameliorated inflammation across the acute models and accelerated excisional wound closure, associated with recruitment of PD-L1 expressing myeloid cells to the wound site.

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.