Autotaxin inhibition reduces cardiac inflammation and mitigates adverse cardiac remodeling after myocardial infarction.
MouseIschaemia-reperfusionCardiacC57BL/6 wild type; Mx1-Cre inducible Plpp3 (LPP3) knockout with Cre-negative littermate controlsFemalen = 10 to 12 mice per group at 30 days for histology and echoca…Intraperitoneal10 mg/kg per doseStarted immediately after myocardial infarction surgery
Model: Permanent left anterior descending coronary artery ligation under isoflurane to induce acute myocardial infarction; shams had the suture passed without tying. Parallel human cohort of 40 STEMI patients and 5 matched controls.
PF-8380 significantly reduced plasma LPA and autotaxin activity and cut cardiac infiltration of neutrophils, Ly6C-high monocytes and activated macrophages, with lower cardiac and splenic IL-1beta, MCP-1 and TNF-alpha and reduced bone marrow progenitor numbers and proliferation. At 30 days treated m…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.