Exosomes from miRNA-126-modified endothelial progenitor cells alleviate brain injury and promote functional recovery after stroke.
MouseIschaemia-reperfusionCerebral (MCAO/stroke)db/db type 2 diabetic recipients; db/c donors for endothelial progenitor cellsn = 143 db/db mice underwent occlusion, 11 died, 132 used; n =…Intravenous, tail veinApproximately 50 microgram total exosome protein per mouse…2 hours after middle cerebral artery occlusion
Model: Middle cerebral artery occlusion induced ischaemic stroke in db/db type 2 diabetic mice
miR-126 mimic transfection raised miR-126 about 4-fold in cells and 6-fold in exosomes without altering exosome size. Injected exosomes co-localised with endothelial cells, neurons, astrocytes and microglia in the peri-infarct area. Exosomes reduced infarct volume on days 2 and 14, with miR-126 enr…
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