Protective Effects of Simvastatin on Endotoxin-Induced Acute Kidney Injury through Activation of Tubular Epithelial Cells' Survival and Hindering Cytochrome C-Mediated Apoptosis.
RatEndotoxin/LPSWistarn = 30 rats in 5 groups of 6Oral gavage, prepared in 0.5 per cent methylcellulose10, 20 or 40 mg/kgPretreatment: 5 days of dosing before LPS, final dose 1.5 h before LPS
Model: Single non-lethal intraperitoneal lipopolysaccharide (serotype O127:B8) challenge at 0.25 LD50/kg (5.5 mg/kg) inducing sepsis-associated acute kidney injury
Simvastatin dose-dependently reduced LPS-induced renal histopathological injury, with renal damage score falling from 3.58 plus or minus 0.50 with LPS alone to 1.42 plus or minus 0.50 at 40 mg/kg. Tubular apoptotic index fell from 34.8 plus or minus 3.6 per cent to 14.0 plus or minus 3.3 per cent a…
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