Docosahexaenoic Acid-Loaded Polylactic Acid Core-Shell Nanofiber Membranes for Regenerative Medicine after Spinal Cord Injury: In Vitro and In Vivo Study
RatSpinal cord injuryHemisection / partialSprague-DawleyFemaleLocal implantation over lesion site (in vivo); co-culture/diffusion (in vitro)Membrane DHA loading 6.23 ± 0.43 μg/mg CSNM (core solution…Implanted at time of SCI surgery
Model: Cervical lateral hemisection spinal cord injury (C4-C5)
PLA/DHA CSNM significantly improved neurological function recovery (grid exploration and cylinder tests) from 1-2 weeks post-SCI compared with PLA-only and untreated controls, reduced neuronal loss, and increased serotonergic nerve sprouting caudal to the lesion; in vitro, sustained DHA release inc…
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