Prophylactic Faecalibacterium prausnitzii treatment prevents the acute breakdown of colonic epithelial barrier in a preclinical model of pelvic radiation disease
RatRadiationSprague DawleyMalen = Approximately 5-12 animals per group per experimental batchIntragastric (oral gavage)1x10^9 CFU administered intragastrically once dailyProphylactic: 3 days before irradiation, day of irradiation, and up to 2 days a…
Model: Single 29 Gy colorectal irradiation (pelvic radiation disease model)
Prophylactic F. prausnitzii treatment reduced radiation-induced histological damage, prevented acute paracellular hyperpermeability and neutrophil infiltration, increased resident macrophages, preserved Sox9+ stem/progenitor cells and Dclk1+/IL-25+ tuft cells, maintained epithelial proliferation an…
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