Ameliorative effect of AT2R and ACE2 activation on ischemic renal injury associated cardiac and hepatic dysfunction.
RatIschaemia-reperfusionRenalWistarMaleC21 intraperitoneal; Dize oralC21 0.3 mg/kg/day; Dize 5 mg/kg/day
Model: Bilateral ischaemic renal injury (bilateral renal ischaemia followed by 24 h reperfusion), in non-diabetic rats and in streptozotocin-induced diabetic rats (streptozotocin 55 mg/kg i.p.)
Ischaemic renal injury produced cardiac and hepatic injury with altered oxidant/antioxidant balance, raised inflammatory signalling and altered RAS component expression. Combined AT2R agonist and ACE2 activator therapy inhibited oxidative stress, downregulated inflammation and enhanced the cardio-h…
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