Efficacy of acute administration of inhaled argon on traumatic brain injury in mice.
MouseTBIControlled cortical impactC57BL/6JMaleInhalationArgon 70% with oxygen 30%Started 10 minutes after traumatic brain injury
Model: Severe traumatic brain injury by controlled cortical impact under anaesthesia
Inhaled argon accelerated sensorimotor recovery and improved cognitive and structural outcome one month after severe traumatic brain injury, with less white matter damage in the ipsilateral fimbria and corpus callosum body. Early effects included reduced pericontusional vasogenic oedema and a reduc…
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