Human Salivary Histatin-1 Is More Efficacious in Promoting Acute Skin Wound Healing Than Acellular Dermal Matrix Paste
MouseWoundC57 (C57BL)Malen = 48 mice across 8 treatment groups (6 per group)Topical applicationHst1 at 1, 10 or 50 μM; ADM alone; ADM + Hst1 at each conce…Applied starting at time of wounding
Model: Full-thickness excisional skin wound (1 cm punch biopsy, dorsal)
Topical 10 μM Hst1 significantly accelerated wound healing from day 3 to day 10, increased epidermal thickness and collagen deposition, increased CD31+ vessel density (2.3-fold) and VEGF expression, and reduced macrophage infiltration and pro-inflammatory markers versus control; ADM paste alone sho…
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