TAK-242 Attenuates Crush Injury Induced Acute Kidney Injury through Inhibiting TLR4/NF-kB Signaling Pathways in Rats.
RatCrushLimb / muscle crushWistarMalen = Part 1: 50 rats, n = 10 per group across control and four c…
Model: Crush injury induced acute kidney injury produced by applying 3 kg pressure for eight hours, with sacrifice at 0, 6, 12 and 24 hours after relief of pressure
Crush injury damaged kidney tissue and raised serum creatinine, blood urea nitrogen, myoglobin, potassium, interleukin-6, tumour necrosis factor alpha and TLR4 mRNA, most markedly at 12 hours. TAK-242 significantly reduced kidney tissue damage and all of these markers together with TLR4 and P65 pro…
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