A Sphingosine-1-Phosphate Receptor Modulator Attenuated Secondary Brain Injury and Improved Neurological Functions of Mice after ICH
MouseHaemorrhage/shockUnspecifiedC57BL/6Nn = 134 mice total, divided into sham and ICH groups with treat…Intraperitoneal0.3 mg/kg (low dose) or 3.0 mg/kg (high dose) in 0.5% DMSOFirst dose 30 minutes post-ICH
Model: Collagenase-induced intracerebral haemorrhage (ICH)
Low-dose Siponimod, particularly with multiple administrations, significantly reduced ICH-induced brain oedema at 72 hours, attenuated ventriculomegaly at 10 days, improved neurological motor function and working memory, and reduced CD3+ lymphocyte brain infiltration; high-dose Siponimod was ineffe…
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