The Effect of MicroRNA-101 on Angiogenesis of Human Umbilical Vein Endothelial Cells during Hypoxia and in Mice with Myocardial Infarction
MouseIschaemia-reperfusionCardiacC57BL/6n = 22 mice analysed: AMI+Adv-miR-101 (n=10, 3 died), AMI+Adv-n…Intramyocardial injection at three points in the left ventricular anterior wall infarct and peri-infarct areaInjected at the time of AMI induction during thoracotomy and coronary ligation…
Model: Acute myocardial infarction via left anterior descending coronary artery ligation
AgomiR-101 enhanced HUVEC proliferation, migration and tube formation in vitro via targeting EIF4E3 and activating HIF-1alpha/VEGF-A signalling; in vivo, adenoviral miR-101 delivery to infarcted myocardium significantly improved left ventricular ejection fraction and fractional shortening, reduced…
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