(+)-Clausenamide protects against drug-induced liver injury by inhibiting hepatocyte ferroptosis
MouseChemical/toxinC57BL/6MaleIntragastric (oral gavage)50 mg/kg/day (also tested up to 100 mg/kg/day), intragastri…Pretreatment for 7 consecutive days before the APAP or erastin challenge
Model: Acetaminophen (APAP)-induced or erastin-induced drug-induced liver injury
(+)-CLA significantly improved liver function and histopathology, reduced hepatocyte death, reversed GSH depletion, and inhibited lipid peroxidation in both APAP- and erastin-induced liver injury models; mechanistically, (+)-CLA restored GPX4 and SLC7A11 levels, indicating inhibition of ferroptosis…
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.