miR-19a/b and miR-20a Promote Wound Healing by Regulating the Inflammatory Response of Keratinocytes.
MouseWoundInjection into the wound edge
Model: Murine excisional skin wounds, including a type 2 diabetes mouse model; human acute wounds and chronic ulcers for expression profiling
Inhibition of miR-19a/b and miR-20a enhanced inflammation and delayed wound closure, whereas keratinocyte overexpression of the miR-17~92 cluster or miR-19b alone accelerated closure. Combined miR-19b plus miR-20a treatment improved healing in a mouse model of type 2 diabetes.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.