Deregulated immune cell recruitment orchestrated by FOXM1 impairs human diabetic wound healing.
MouseWoundCD1 (streptozotocin-induced diabetes) and db/db miceMale and femalen = 13 diabetic foot ulcer patients; mouse n per group not stat…Topical application to the wound, covered with film dressing150 micromolar FDI-6Applied at the time of wounding
Model: Two 6 mm full-thickness excisional punch wounds on shaved dorsal skin. Diabetic models: streptozotocin 60 mg/kg intraperitoneally for 5 consecutive days with diabetes maintained 6 weeks before wounding, and db/db mice. Human arm: chronic diabetic foot ulcer wound-edge biopsies
Topical FDI-6 significantly inhibited wound healing versus vehicle at day 4 in non-diabetic mice and further delayed healing in streptozotocin diabetic mice, with reduced immune cell infiltrate and significantly fewer neutrophils and macrophages in both streptozotocin and db/db wounds. The harm is…
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