The protective effects of C16 peptide and angiopoietin-1 compound in lipopolysaccharide-induced acute respiratory distress syndrome.
RatEndotoxin/LPSWistarmalen = n = 15 per group in the survival analysis4 h following lipopolysaccharide injection
Model: Lipopolysaccharide-induced acute respiratory distress syndrome in rats, plus human pulmonary microvascular endothelial and alveolar epithelial cell culture
Combined treatment reduced inflammatory cell transmigration by 33 per cent, lowered lung wet-to-dry ratio to a maximum of 1.53 versus 3.55 in vehicle, cut histology injury score to 60 per cent of vehicle, improved blood gases, and raised survival from 7 of 15 to 12 of 15.
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