Microenvironment-responsive immunoregulatory electrospun fibers for promoting nerve function recovery.
RatSpinal cord injuryHemisection / partialSprague-Dawleyfemalen = 330 female Sprague-Dawley rats randomly divided into six gr…Local implantation into the spinal cord hemi-section defectFibre bundles of 2 mm x 2 mm x 3 mm placed inside the defectImmediately after creation of the defect, during the same surgery
Model: Acute spinal cord hemi-section defect (3 mm) at T9
The immunoregulatory fibre scaffold shifted immune cell subtypes, down-regulated the acute inflammatory response, reduced scar tissue formation, promoted angiogenesis and neural differentiation at the injury site, and enhanced functional recovery in vivo.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.