Administration of cardiac mesenchymal cells modulates innate immunity in the acute phase of myocardial infarction in mice.
MouseIschaemia-reperfusionCardiacC57BL/6JfemaleIntramyocardial injection into the peri-infarct region using a 30-gauge needle0.5 x 10^6 cardiac mesenchymal cells in 40 uL sterile phosp…48 hours after myocardial infarction
Model: Myocardial infarction by 60-minute coronary occlusion followed by reperfusion
Cardiac mesenchymal cell administration preferentially recruited innate immune cells such as monocytes/macrophages and neutrophils, and paracrine signalling enhanced innate immune cell chemoattraction, survival and phagocytosis while diminishing pro-inflammatory activation.
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