Serpina3n is closely associated with fibrotic procession and knockdown ameliorates bleomycin-induced pulmonary fibrosis.
MouseChemical/toxin
Model: Bleomycin-induced pulmonary fibrosis, with a parallel silica-induced model
Serpina3n was up-regulated in both silica and bleomycin models, peaking at week 3 and returning towards normal by week 10, and AAV-mediated knockdown in lung tissue alleviated bleomycin-induced fibrotic changes while disinhibiting chymotrypsin C.
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