Bee Venom Melittin Protects against Cisplatin-Induced Acute Kidney Injury in Mice via the Regulation of M2 Macrophage Activation.
MouseChemical/toxinC57malen = n = 6-8 per group across 5 groups (blank, cisplatin, melitt…intraperitoneal injection10, 50 or 100 ug/kg melittinPretreatment: melittin given daily for 5 days, with cisplatin administered the…
Model: Cisplatin-induced acute kidney injury (cisplatin 15 mg/kg)
Melittin inhibited the cisplatin-induced rise in creatinine and blood urea nitrogen, significantly decreased M1 marker expression and increased M2 markers, and substantially reduced tubular necrosis.
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