Nephroprotective Effect of Cilastatin against Gentamicin-Induced Renal Injury In Vitro and In Vivo without Altering Its Bactericidal Efficiency.
RatChemical/toxinWistarmalen = 28 rats in 4 groups: untreated control n = 6, cilastatin n…intraperitonealCilastatin 150 mg/kg (0.5 mL/kg); gentamicin 80 mg/kg (5 mL…Cilastatin given immediately before each gentamicin dose, from the first gentam…
Model: Gentamicin-induced acute kidney injury (gentamicin 80 mg/kg), with porcine renal cells in vitro
Cilastatin decreased creatinine, blood urea nitrogen, kidney injury molecule-1 and severe morphological changes caused by gentamicin, reduced megalin expression, gentamicin uptake and myeloid body formation, and lowered apoptotic, oxidative and inflammatory markers without preventing gentamicin bac…
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