Protective effects of isorhynchophylline against silicon-dioxide-induced lung injury in mice.
MouseChemical/toxinmaleintraperitoneal injection20 mg/kgImmediately after silicon dioxide exposure, once the mice had woken up
Model: Silicon dioxide-induced acute lung injury and pulmonary fibrosis (single dose 2.5 mg/kg intranasal inoculation)
After 14 days isorhynchophylline significantly reduced pulmonary inflammatory cell infiltration and bronchoalveolar lavage pro-inflammatory factor levels, and after 42 days it alleviated inflammation, inhibited fibrogenic factor release and significantly reduced collagen deposition.
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